Journal of the Medical Association of Thailand Vol 93, No 11:NOVEMBER 2010 0125-2208 93 11 2010 Nov Double Check Up of Malignancy Biopsy Specimens for Patient Safety 1310 EN Pattana Sornmayura Yingluck Visessiri Mana Rochanawutanon Vorachai Sirikulchayanonta Rangsima Aroonroch Wasana Kanoksil Noppadol Larbcharoensub Sansanee Wongwaisayawan Juvady Leopairut Panas Chalermsanyakorn Suchin Worawichawong Niramol Chanplakorn Paisan Leelachaikul Atcharaporn Pongtippan Original Article To detect and correct the errors or the significant discrepancies in the diagnosis of biopsy specimens before signoutand to determine the frequency of anatomic pathology significant discrepancies.Design: The application of the mutually agreed work instructions (record) for the detection of errors or the significantdiscrepancies and their process of sign-out. The record of biopsy specimen that received a secondary check (1,959 cases,2005-2007) was analyzed.Results: After a secondary check, 53 cases of non-malignancy for any reason by a second pathologist were included.However, when using our definition on significant discrepancies, only 37 cases were considered. Another seven cases with theopinions with malignancy that were of different cell types that do harm to the patients were added. Therefore, 44 cases (2.25%)had truly significant discrepancies.Conclusion: The truly significant discrepancy frequency was 2.25% during the p After a secondary check, 53 cases of non-malignancy for any reason by a second pathologist were included.However, when using our definition on significant discrepancies, only 37 cases were considered. Another seven cases with theopinions with malignancy that were of different cell types that do harm to the patients were added. Therefore, 44 cases (2.25%)had truly significant discrepancies. The truly significant discrepancy frequency was 2.25% during the process of pre-sign-out secondary check ofmalignancy of biopsy specimens. The project has been applied as a routine daily work. It can be an innovative safety programfor patient in Thailand. Patient safety Quality improvement Quality assurance Surgical pathology Malignancy