Journal of the Medical Association of Thailand Vol 98, No 9:SEPTEMBER 2015 0125-2208 98 9 2015 Sep Impaired Reach-to-Grasp Actions during Barrier Avoidance in Individuals with Parkinson’s Disease 889 EN Suweena Khacharoen Jarugool Tretriluxana Pakaratee Chaiyawat Apichart Pisarnpong Original Article To determine the kinematics and coordination while performing reach-to-grasp (RTG) actions under barrier avoidance condition in individuals with Parkinson’s disease (PD). Right handed idiopathic PDs (Hoehn and Yahr stage 2-3) (n = 20) and age-matched controls (n = 10) without dementia and psychological impairment were recruited. They were asked to perform RTG “as soon as you see the light and as fast as you can” with their right hands under barrier condition. The RTG performance were assessed in three domains, planning, execution (or kinematics), and coordination. The planning was measured by reaction time. The kinematics variables were movement time, maximum velocity, time to maximum velocity, deceleration time, maximum aperture, time to maximum aperture, aperture closure time, and aperture closure distance. The coordination was assessed using a cross correlation analysis between transport velocity and aperture size, which consisted of maximal correlation oefficient (rmax ) and associated time lag (Tmax ). Compared to the controls, the PD group had delayed planning. In execution domain, they showed decreased maximum velocity, smaller amplitude of maximum aperture, and prolonged all raw times comparing to controls. When considering the coordination, they had only prolonged Tmax than controls. PD participants with mild to moderate impairment showed poorer RTG planning, execution, and coordination during barrier avoidance when compared to age-matched controls. Reach to grasp Parkinson’s disease Barrier task Manual coordination