Journal of the Medical Association of Thailand Vol 101, No 2:FEBRUARY 2018 0125-2208 101 2 2018 Mar Comparative Effectiveness of Mindfulness-Based Therapy in Sleep Quality of Chronic Insomnia Compared to Standard Cognitive Behavioral Therapy [CBT-I]: A Randomized Controlled Trial 269-73 EN Jarturong Siritienthong Tantawan Awirutworakul Sakda Vallibhakara Original Article To find the influences of mindfulness-based approach and compare them with standard treatment outcomes. Prospective randomized control trial was conducted by two treatment groups (n = 10 each) for eight-week duration. Sleep-related parameters consisted of the Clinical Global Impression - severity [CGI-S], the Pittsburgh Sleep Quality Index-Thai version [Thai-PSQI], the Hospital Anxiety and Depression Scale Thai version [Thai HADS] and the Philadelphia Mindfulness Scale [PHLMS] were collected before and after both treatments. Mindfulness-based group had statistically significant improvement of better sleep quality and clinical impression improvement-severity (p-value 0.0032 and <0.0001, respectively). Mindfulness level and sleep profiles improved, although there was no significant difference when both treatments were compared. Mindfulness-based intervention improves sleep quality, and could be decreased impact of daily-life stress and lowered severity of insomnia symptoms. Mindfulness Sleep disturbance Insomnia Thai-PSQI CGI-S PHLMS Thai HADS CBT-I