Journal of the Medical Association of Thailand Vol 93, No 1:JANUARY 2010 (SUPPL.1) 0125-2208 93 1 2010 Jan IgE Production in Allergic Asthmatic Patients with Different Asthma Control Status 71 EN Kittipong Maneechotesuwan Pimtira Sujaritwongsanon Tasneeya Suthamsmai Original Article To determine the amount of total serum IgE among allergic asthmatic patients with various asthmacontrols. A total of 190 non-smoking patients with allergic asthma were divided into threegroups by using the asthma control definition according to the GINA 2006 criteria. There were 64 wellcontrolled,88 partly-controlled, and 38 uncontrolled. After study entry, patients underwent lung functiontest, methacholine challenge and skin prick test to establish allergic status. Peripheral venous blood specimenswere collected to measure total IgE and absolute eosinophil numbers. The data are expressed as mean +SD. The logarithm of total serum IgE was significantly higher in subjects with uncontrolled allergicasthma than in those with well-controlled disease (p < .0001). IgE response in uncontrolled asthmatics wasstill high despite having been treated with ICS at a dose which was significantly high when compared withwell-controlled subjects (1075.4 + 420 vs. 703.5 + 355, p < .0001). The logarithm of total serum IgE wasassociated with increased blood eosinophil counts (r = 0.25, p .0007) among three asthmatic groups and withdecreased prebronchodilator FEV1 (r = -0.42, p = .0075) and PC20 (r = -0.36, p = .04) only in uncontrolledgroup. In allergic asthmatic patients with various disease control stages, there are differences in IgEimmune response. Both high and non-suppressible total serum IgE response may be involved in the developmentof uncontrolled asthma. Allergic asthma; Asthma control; Immunoglobulin E