Journal of the Medical Association of Thailand Vol 104, No 10:OCTOBER 2021 0125-2208 104 10 2021 Oct Evaluating the Effect of Volten VR4® Kaempferia parviflora Extracts on Blood Glucose Levels in Human Type-2 Diabetes Mellitus and Healthy Individual: A Case-Control Study 1610-6 EN Ahmad Mohamad Muhammad Nordin Ismail Ani Johan Jemberang Reezal Ishak Ahmad Hasan Muhammad Ahmad Mohd Omar Roszymah Hamzah Original Article To evaluate the efficacy of Volten VR4® on healthy individuals and Type-2 Diabetes Mellitus volunteers. The extracts of 400 mg capsules of KP were consumed for five days. The fasting and blood glucose levels of 2-hour postprandial were measured at baseline and day 5. A group of 15 healthy young adults between the age of 20- and 30-years old were the control group of the present study, while 12 volunteers aged 35 to 75 years old diagnosed with Type-2 Diabetes Mellitus constituted the experimental group. Data were validated through the Willcoxon and Friedman test statistics and error distribution. It had been shown that the specificity of KP reduced blood glucose levels and has associated with the flavonoids and polymethoxyflavones components. The results showed that consuming VR4® capsules significantly reduced blood glucose, either at the state of fasting or postprandially in diabetic individual. Volten VR4® Kaempferia parviflora extract is safe to be consumed at 400 mg at one time. The study also has shown that the participants are free from adverse reactions and hypoglycaemia. Kaempferia parviflora; Blood glucose; Type-2 Diabetes Mellitus; Flavonoids; Polymethoxyflavones; Hypoglycemia and heavy metal elementsDOI: doi.org/10.35755/jmedassocthai.2021.10.12751Received 5 April 2021 | Revised 30 August 2021 | Accepted 30 August 2021