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Original ArticleOpen Access
Randomized Comparison of Fluorouracil Plus Cisplatin vs. Cisplatin as an Adjunct to Radiation Therapy in Stage IIB- IVA Squamous Cell Carcinoma of the Cervix: Pilot Study
Sukhaboon J 
,
Porapakkhan P ,
Penpattanagul S
,
Porapakkhan P ,
Penpattanagul S Objective: To compare the efficacy and toxicity of pelvic radiotherapy with concomitant cisplatin plus
fluorouracil versus cisplatin alone in patients with locally advanced squamous cell cervical cancer.
Material and Method: Twenty women with squamous cell cervical cancer were randomly assigned to receive
ether standard whole pelvic radiotherapy with concurrent cisplatin and fluorouracil infusion every 4 weeks
or the same radiotherapy with concurrent cisplatin every 1 week. The primary end point was the response rate.
Results: All patients in cisplatin plus fluorouracil regimen and in cisplatin regimen had complete response.
In cisplatin group there was higher frequencies of adverse hematologic effects. Grade 3 or 4 neutropenia
occurred in 10% of the cisplatin plus fluorouracil group and in 40% of the cisplatin group (p = 0.049).
Conclusion: No difference was found in the response rate, but higher frequencies of hemotological adverse
effects in the cisplatin group.
Keywords: Chemotherapy, Cisplatin, Drug therapy, Fluorouracil, Radiotherapy, Uterine cervical neoplasms
fluorouracil versus cisplatin alone in patients with locally advanced squamous cell cervical cancer.
Material and Method: Twenty women with squamous cell cervical cancer were randomly assigned to receive
ether standard whole pelvic radiotherapy with concurrent cisplatin and fluorouracil infusion every 4 weeks
or the same radiotherapy with concurrent cisplatin every 1 week. The primary end point was the response rate.
Results: All patients in cisplatin plus fluorouracil regimen and in cisplatin regimen had complete response.
In cisplatin group there was higher frequencies of adverse hematologic effects. Grade 3 or 4 neutropenia
occurred in 10% of the cisplatin plus fluorouracil group and in 40% of the cisplatin group (p = 0.049).
Conclusion: No difference was found in the response rate, but higher frequencies of hemotological adverse
effects in the cisplatin group.
Keywords: Chemotherapy, Cisplatin, Drug therapy, Fluorouracil, Radiotherapy, Uterine cervical neoplasms
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