Multiple dose activated charcoal (MDAC) is used to enhance elimination of toxic substance in acute
poisoning. However, its role in acute valproic acid (VA) overdose is controversial. The authors report a case
of VA overdose that successfully recovered with MDAC treatment. The half-life of VA in the presented patient
was decreased from 12 to 8 hours during MDAC administration. MDAC treatment in acute poisoning
enhanced VA elimination four times than without treatment. MDAC should be considered for the treatment of
acute VA intoxication.

Keywords: Valproic acid, Toxicity, Multiple dose activated charcoal, Hemodialysis