Background: Cerebral palsy (CP) causes patients to experience developmental delays, affecting self-help. CP has many risk factors, unfortunately, no total risk summarization exists now.

Objective: To study the risk factors for neonate CP, making it possible to diagnosis early and reduce complications.

Materials and Methods: The present study was a retrospective case control study in children aged 0 to 2 years, born at Thammasat University Hospital, Thailand between 2005 and 2014. Multivariable logistic regression compared perinatal period risks between normal children (control) and those with CP (case).

Results: Within the multivariable logistic regression evaluation, CP risk factors were cerebral and non-cerebral malformations, low birthweight, neonatal sepsis, with adjusted odds ratio 250.43, 16.04, 32.60, and 63.15, respectively.

Conclusion: Cerebral and non-cerebral malformations, low birthweight, and neonatal sepsis are CP predictive risks. However, multi-fetal gestation, preterm birth, low Apgar score, fetal distress, uterine and cord anomalies, maternal infection, neonatal seizure, neonatal encephalopathy, congenital infections, and use of ventilator remain undetermined. A multicenter research incorporating the other events is needed.

Keywords: Cerebral palsy, Risk factors, Prenatal, Perinatal, Postnatal

DOI: doi.org/10.35755/jmedassocthai.2020.07.10084

Received 27 Jan 2020 | Revised 31 Mar 2020 | Accepted 3 Apr 2020