Objectives: To determine the prevalence and factors related to failure to receive hormonal replacement therapy (HRT (after bilateral oophorectomy in women aged 45 years or younger

Materials and Methods:A retrospective descriptive study was conducted in patients who underwent bilateral oophorectomy during January 2009 to December 2013 in Faculty of Medicine Vajira Hospital. Inclusion criteria were age 18-45 years old and had complete ovarian tissue removed. Exclusion criteria were women who had contraindication to HRT.

Results:A total of 183 patients had some types of gynecologic surgery including bilateral oophorectomy during the study period. Eighteen patients were excluded due to the following contraindications: incomplete ovarian removal (9 patients), history of breast cancer (5 patients) or deep vein thrombosis (4patients). The median age of 165 patients included in the study was 40.6 years (range 24-45 years) with the median BMI of 24.3 kg/m² (range 23.8-40.2 kg/m²). The most common indication for surgery was adenomyosis with or without endometriosis (54.5%). The prevalence of failure to receive HRT was 52.7%. Factors significant related to the failure were having gynecologic malignancy and age older than 40 years.