Background: Chronic liver disease is a worldwide problem with many causes and varying degree of fibrosis that end up with cirrhosis. Several ultrasound elastography techniques have been introduced to assessment liver pathologic and fibrosis stage. New techniques and machines were developed for the last years.

Objective: To compare the reliability of method for evaluation the liver stiffness measurements head to head by three techniques of shear wave elastography: point shear wave (P-SWE: ElastPQ) and 2D shear wave elastography (2D-SWE: ElastQ and LOGIQTM E9) and analyze the factor influence realiablity measurement.

Materials and Methods: The present study was a retrospective study of 801 patients with liver disease in Rajavithi Hospital between September 2017 and March 2018, evaluated measurement by point shear wave elastography and 2D shear wave elastography. Then compared percentage reliability measurement and performing time of three methods.

Results: Eight hundred and one patients with liver disease, mean age + SD was 51.6+12.94 years (range 20 to 84), 56.1% were male. The percentage of success rate more than 60% of 2D LOGIQTM E9, 2D ElastQ and P-SWE (Elast PQ) were 99,94.9 and 70.4 that show a significant difference (p<0.001). The IQR/median are 99.9, 99.3 and 97.9 that show the significant difference of 2D-SWE LOGIQTM E9 and P-SWE (p<0.001). The measurement values and performing time were correlated with reliable measurement.

Conclusion: The reliable measurement difference between method and machine. 2D-SWE (LOGIQTM E9, ElastQ) give reliability (IQR/mean) and reliable measurement better than P-SWE (ElastPQ), statistically significant. The reliable measurement is related to liver stiffness value and performing time. Other factors show no significant influence on reliable measurement.

Keywords: Liver stiffness, Shear wave elastography (SWE), Point shear wave elastography (P-SWE), 2D shear wave elastography
(2D-SWE), Reliability, Reliability measurement, Liver stiffness measurement (LSM)