Objective: To determine whether the remote ischemic pre-conditioning (RIPC) reduces myocardial ischemia in patients undergoing elective coronary artery bypass graft (CABG) surgery.

Materials and Methods: The present study was a single-center, triple-blinded, randomized controlled trial. Fifty patients undergoing elective coronary artery bypass graft surgery were assigned to either RIPC or control treatment. Ischemic preconditioning consisted of three cycles of 5-minute of lower limb ischemia and reperfusion (cuff inflation and deflation) after anesthesia induction. Myocardial ischemia was assessed based on serum high-sensitivity cardiac troponin T (hs-cTnT).

Results: There was no significant difference in hs-cTnT levels between the RIPC group and the control group. Furthermore, there were no significant differences in inotropic drug use, acute kidney injury, mechanical ventilation time, hospital stay, or 30-day mortality. However, patients in the RIPC group had a significantly shorter length of stay in the intensive care unit (ICU).

Conclusion: Although RIPC did not reduce myocardial ischemia after CABG surgery, it did decrease the length of patients’ stays in the ICU.

Keywords: Remote ischemic preconditioning, Coronary artery bypass graft, Myocardial ischemia, Troponin

Received 25 Sep 2019 | Revised 19 Nov 2019 | Accepted 20 Nov 2019