Background: There are many methods used to estimate renal function in routine clinical practice. Good correlation between glomerular filtration rate (GFR) by Tc-99m DTPA renal scan and inulin clearance is the gold standard method of determining GFR.

Objective: The aim of the present study was to evaluate renal function by GFR by Tc-99m DTPA renography and compare it between serum creatinine (Cr), serum blood urea nitrogen (BUN), estimated GFR (eGFR) by Chronic Kidney Disease Epidemiology Collaboration equation (CKDEPI equation), and 24-hour urine creatinine clearance in Thai living related kidney donors. The secondary aim was to investigate whether age or body mass index (BMI) would have a significant effect to the evaluation of GFR from Tc-99m DTPA renography.

Materials and Methods: The present study was a retrospective study that included potential living kidney donors who underwent Tc-99m DTPA renal scan and renogram at Siriraj Hospital (Bangkok, Thailand) to evaluate renal function between January 2011 and January 2018. All included patients had complete GFR data from Tc-99m DTPA renography, serum Cr, serum BUN, eGFR by CKD-EPI equation, and 24-hour urine creatinine clearance. Age, gender, and BMI data were also collected.

Results: One hundred twenty cases were included. There were 72 females and 48 males, and the mean age was 36.72±10.22 years with a range of 19 to 58 years. Significant correlation was observed between GFR from Tc-99m DTPA renography and serum Cr, serum BUN, eGFR by CKD-EPI equation, and 24-hour urine creatinine clearance. In contrast, gender and BMI revealed no significance with GFR from Tc-99m DTPA renography. Significant negative correlation was found between GFR from Tc-99m DTPA renography and age.

Conclusion: The results of the present study revealed that serum Cr, serum BUN, eGFR by CKD-EPI equation, and 24-hour urine creatinine clearance were reliable methods for evaluating GFR. Older age significantly correlated with reduction of the GFR value from Tc-99m DTPA renography.

Keywords: GFR; Renal function; Glomerular filtration rate; Tc-99m DTPA renography; Serum creatinine; BUN; CKD-EPI equation; Urine 24 hours creatinine clearance

DOI: 10.35755/jmedassocthai.2022.08.10778

Received 6 November 2019 | Revised 13 June 2022 | Accepted 15 June 2022