Background: Pruritus following major burns affects the functional and psychological qualities of life of severe-injury survivors. The treatment for refractory cases is limited, with only fair outcomes.

Objective: This case series evaluated a new choice of treatment for post-burn pruritus cases.

Materials and Methods: Severe, post-burn, pruritus cases at the Burns Unit of Siriraj Hospital were enrolled. A glycerin-based, highly concentrated, collagen lotion was applied in combination with an oral, anti-itching medication to treat severe, post-burn pruritus. Visual analog scale scores for itching, modified Vancouver Scar Scale scores, and the quality of life of all cases were compared pre- and post-treatment.

Results: Five severe, post-burn, pruritus cases participated in this study. After treatment, the subjects’ visual analog scores for itching, total itching hours, and quality of life improved.

Conclusion: A glycerin-based, highly concentrated, collagen lotion can improve the skin moisture balance, scar appearance, pruritussymptom severity, and quality of life of severe post-burn pruritus cases.

Keywords: Post burn pruritus, Burn scar pruritus, Collagen lotion, Post burn pruritus treatment