In this article, we report the case of a 39-years-old man who presented with a rapidly growing mass at his right cheek.
The result of investigations was compatible with non-ossifying fibroma with secondary aneurysmal bone cyst that involved the
right zygoma, maxilla, and orbital floor. This patient was treated with CAD/CAM 3D virtual surgery that designed and developed a
customized 3D cutting guide for maxillectomy, and a customized 3D titanium mesh plate for defect reconstruction. The procedure
was clinically successful, and the patient was very satisfied with the functional and aesthetic outcomes. This surgical technology
was adopted at our center in 2018 to treat patients requiring maxillofacial surgery and defect reconstruction, and this report
profiles the first patient who had pathology at maxillary bone and treated with this surgical method.

Keywords: Customized 3D cutting guide, Customized 3D titanium mesh plate, Maxillectomy and maxillary defect reconstruction, Thailand