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Original ArticleOpen Access
Adverse Effect of Pioglitazone in Military Personnel and Their Families: A Preliminary Report
Vudhironarit T 
,
Benjasuratwong Y ,
Patarakitvanit S ,
Temboonkiat S ,
Satyapan N
,
Benjasuratwong Y ,
Patarakitvanit S ,
Temboonkiat S ,
Satyapan N Background: Thiazolidinediones (rosiglitazone and pioglitazone) whether administered alone or in combination
with metformin, sulfonylurea, or insulin, are often accompanied by an increase in weight and/or
plasma volume. Several studies have shown the adverse effect of weight gain and edema with rosiglitazone.
But there was less data with pioglitazone, especially in military personnel and their families.
Material and Method: The authors prospectively recorded the adverse events in 40 patients with type 2
diabetes mellitus who underwent administration with pioglitazone 15 mg once daily between June 2005 to
May 2007.
Results: Weight gain was reported in 30/40 of patients (75 %). The mean weight gain was 2.25 + 2.23 kg and
the median was 2 kg. The slightly lower proportion of patients, 21/40 (52.5 %) developed edema and some of
them were associated with weight gain.
Conclusion: Pioglitazone was associated with a significant increase in body weight and edema. This finding
may lead to increase the risk of myocardial infarction in military personnel and their families, especially those
who had underlying disease of congestive heart failure, which was not included in the present study.
Keywords: Pioglitazone, Weight gain, Edema, Military personnel
with metformin, sulfonylurea, or insulin, are often accompanied by an increase in weight and/or
plasma volume. Several studies have shown the adverse effect of weight gain and edema with rosiglitazone.
But there was less data with pioglitazone, especially in military personnel and their families.
Material and Method: The authors prospectively recorded the adverse events in 40 patients with type 2
diabetes mellitus who underwent administration with pioglitazone 15 mg once daily between June 2005 to
May 2007.
Results: Weight gain was reported in 30/40 of patients (75 %). The mean weight gain was 2.25 + 2.23 kg and
the median was 2 kg. The slightly lower proportion of patients, 21/40 (52.5 %) developed edema and some of
them were associated with weight gain.
Conclusion: Pioglitazone was associated with a significant increase in body weight and edema. This finding
may lead to increase the risk of myocardial infarction in military personnel and their families, especially those
who had underlying disease of congestive heart failure, which was not included in the present study.
Keywords: Pioglitazone, Weight gain, Edema, Military personnel
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