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Original ArticleOpen Access
Non-Diabetic Glomerular Disease in Type II DM: 10 Years Experience
Chawarnkul O 
,
Vareesangthip K ,
Ongajyooth L ,
Cheunsuchon B ,
Parichatikanond P
,
Vareesangthip K ,
Ongajyooth L ,
Cheunsuchon B ,
Parichatikanond P Background: The nature of renal damage in patients with type II diabetes remains unclear.
Objective: To analyze the renal histopathology in type II diabetes who underwent renal biopsy at Siriraj
Hospital, renal unit over 10 year period.
Material and Method: The clinical and biochemical data in 54 patients with Type II DM, atypical cases of DN,
were subjected to renal biopsy and analyzed retrospectively.
Results: Ten out of fifty-four type II diabetic patients (18.5%) were diagnosed non-diabetic nephropathy
(NDN); there were 4 patients with membranous GN, 3 patients with crescentic GN1 patient of MPGN type I, 1
patient with renal change from hypertension and 1 patient with IgMN. The most important factor that had
statistically significant was nephritis urine sediment (NDN: DN 40% vs. 4.5%), However 60% of NDN had no
nephritic urine sediment.
Conclusion: There was no strong predictor to differentiate DN from NDN by clinical or biochemical data. The
only significant finding in NDN was nephritic urine sediment.
Keywords: Diabetes mellitus type 2, Diabetic nephropathies, NDN
Objective: To analyze the renal histopathology in type II diabetes who underwent renal biopsy at Siriraj
Hospital, renal unit over 10 year period.
Material and Method: The clinical and biochemical data in 54 patients with Type II DM, atypical cases of DN,
were subjected to renal biopsy and analyzed retrospectively.
Results: Ten out of fifty-four type II diabetic patients (18.5%) were diagnosed non-diabetic nephropathy
(NDN); there were 4 patients with membranous GN, 3 patients with crescentic GN1 patient of MPGN type I, 1
patient with renal change from hypertension and 1 patient with IgMN. The most important factor that had
statistically significant was nephritis urine sediment (NDN: DN 40% vs. 4.5%), However 60% of NDN had no
nephritic urine sediment.
Conclusion: There was no strong predictor to differentiate DN from NDN by clinical or biochemical data. The
only significant finding in NDN was nephritic urine sediment.
Keywords: Diabetes mellitus type 2, Diabetic nephropathies, NDN
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