J Med Assoc Thai 2021; 104 (1):159-63

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Abacavir Hypersensitivity Reaction: The First Case Report in Thailand and Literature Review
Chinudomporn C , Thititagul O , Tantisiriwat W Mail

Abacavir-related hypersensitivity reaction (ABC-HSR) is a life-threatening condition. The incidence is low since it could have been prevented by screening with blood test for HLA-B*5701, which is strongly associated with this reaction. However, the affordability for the HLA-B*5701 screening test is still a challenging issue in many developing countries. Thai National Health Security Office (NHSO) recommends either using HLA-B*5701 as a screening test or monitoring clinical presentation for ABC-HSR after using it. Therefore, the clinical presentation of ABC-HSR should be acknowledged for the diagnosis of this condition and death prevention. This was the first reported case and literature reviewed of ABC-HSR associated with the presence of the HLA-B*5701 allele in Thailand.

Keywords: Abacavir, Hypersensitivity reaction, HLA-B*5701, Clinical presentation, Thailand

DOI: doi.org/10.35755/jmedassocthai.2021.01.11569

Received 16 June 2020 | Revised 20 August 2020 | Accepted 21 August 2020

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