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Original ArticleOpen Access
Long-Term Study of Escherichia coli and Klebsiella pneumoniae Isolates Producing Extended-Spectrum Beta-Lactamases
Polwichai P 
,
Trakulsomboon S ,
Dejsirilert S ,
Thongmali O ,
Sawanpanyalert P ,
Aswapokee N ,
Buppanharun W
,
Trakulsomboon S ,
Dejsirilert S ,
Thongmali O ,
Sawanpanyalert P ,
Aswapokee N ,
Buppanharun W Objective: To evaluate the prevalence and susceptibility pattern of Escherichia coli and Klebsiella pneumoniae
isolates producing extended-spectrum beta-lactamases (ESBLs) in Thailand from 2000 to 2005.
Material and Method: Data on the WHONET, from 28 hospitals participated in the National Antimicrobial
Resistance Surveillance, Thailand surveillance program, were reviewed and analyzed for the prevalence and
susceptibility pattern.
Results: During the five-year surveillance from 2000 to 2005, the prevalence of ESBL-producing E. coli
detected by ceftazidime screening test was 17%, 21.3%, 23.2%, 20.4%, 23.1%, and 25.0%; as well as detected
by cefotaxime screening test was 20.8%, 65.9%, 69.3%, 69.3%, 68.3%, and 33.8%, respectively. The
prevalence of ESBL-producing K. pneumoniae detected by ceftazidime screening test was 30.9%, 34.7%,
32.5%, 34.4%, 37.2%, and 39.2%; as well as detected by cefotaxime screening test 38.4%, 39.3%, 40.1%,
41.0%, 42.8%, and 40.4%, respectively.
Conclusion: From 2000 to 2005, the prevalence of ESBL-producing organisms in Thailand was high.
ESBL-producing E. coli was most commonly isolated from sputum, followed by blood and urine specimens.
ESBL-producing K. pneumoniae had not been increasingly isolated from sputum, blood, and urine.
Keywords: Escherichia coli, Klebsiella pneumoniae, Beta-lactamases, Thailand
isolates producing extended-spectrum beta-lactamases (ESBLs) in Thailand from 2000 to 2005.
Material and Method: Data on the WHONET, from 28 hospitals participated in the National Antimicrobial
Resistance Surveillance, Thailand surveillance program, were reviewed and analyzed for the prevalence and
susceptibility pattern.
Results: During the five-year surveillance from 2000 to 2005, the prevalence of ESBL-producing E. coli
detected by ceftazidime screening test was 17%, 21.3%, 23.2%, 20.4%, 23.1%, and 25.0%; as well as detected
by cefotaxime screening test was 20.8%, 65.9%, 69.3%, 69.3%, 68.3%, and 33.8%, respectively. The
prevalence of ESBL-producing K. pneumoniae detected by ceftazidime screening test was 30.9%, 34.7%,
32.5%, 34.4%, 37.2%, and 39.2%; as well as detected by cefotaxime screening test 38.4%, 39.3%, 40.1%,
41.0%, 42.8%, and 40.4%, respectively.
Conclusion: From 2000 to 2005, the prevalence of ESBL-producing organisms in Thailand was high.
ESBL-producing E. coli was most commonly isolated from sputum, followed by blood and urine specimens.
ESBL-producing K. pneumoniae had not been increasingly isolated from sputum, blood, and urine.
Keywords: Escherichia coli, Klebsiella pneumoniae, Beta-lactamases, Thailand
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