The recommended dose of Menatretenone is 45 mg three times a day; however, the compliant in daily
practice is not convenient.This study shows the twice dose per day is inferior to the recommended dose. This
study used the level of Gla protein in osteocalcin as a parameter for the comparison. The mean of three-time
dose a day is 11.27 nanogram per milliliter while the mean of the other group is 6.07 nanogram per milliliter
after the three-month treatment.

Keywords: Dose, Menatretenone