J Med Assoc Thai 2020; 103 (12):82-85

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Relationship between Hepatic Steatosis and Outcome of Viral Hepatitis C Treatment
Akarapatima K Mail, Sattayaraksa T , Chang A , Rattanasupar A

Background: Hepatitis C virus (HCV) infection is an important cause of liver disease. The correlation between hepatic steatosis and HCV treatment results is unclear. Majority of studies showed that hepatic steatosis decreases efficacy of treatment while some showed no correlation. Noninvasive modalities (transient elastrography; TE) have recently largely supplanted liver biopsy, which may limit recognition of steatosis. The controlled attenuation parameter (CAP) from TE is a parameter to identify hepatic steatosis.
Objective: To determine the correlation between hepatic steatosis and sustained virological response (SVR).
Materials and Methods: The retrospective study analyzed data from HCV infected patients in the hepatitis clinic of Hatyai Hospital between 2014 and 2017. All patients were measured for CAP before treatment. The correlation between hepatic steatosis and SVR was analyzed.
Results: Seventy four HCV infected patients participated in the present study. Twenty five percent of participants were hepatic
steatosis (n = 15). SVR was 80% in hepatic steatosis group and 71.2% in group without hepatic steatosis (p = 0.50). Other factors showed no significant except significant fibrosis.
Conclusion: There was no relationship between hepatic steatosis and HCV treatment outcome.

Keywords: Controlled attenuation parameter, CAP, Hepatic steatosis, Outcome, Viral hepatitis C, Treatment


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