Background: Trauma injury is the leading cause of death in Thailand. Multiple injury patients who receive nursing intervention according to the clinical nursing practice guideline for multiple injury patients are thought to be safer and less likely to experience complications. However, outcomes of using the guideline have yet to be systematically evaluated.
Objective: The present study aimed to assess outcomes experienced by multiple injury patients after implementation of the clinical nursing practice guideline.
Materials and Methods: The present study was a retrospective study. Patients enrolled in the study were over 18 years old and had been admitted to the Emergency Department of Srinagarind Hospital between January and December 2019 with an injury severity score (ISS) greater than or equal to 16.
Results: A total of 83 patients were enrolled, 70 (84.34%) of whom were male. The mean age of the patients was 36.33 years. Most of the injuries were caused by blunt force trauma (98.80%). The mean ISS was 28.10+8.50. The clinical nursing practice guideline for multiple injury patients had a 96.71% adherence rate, with 5 activities that had a 100% adherence rate: triage, circulation with hemorrhage control, disability assessment, exposure & environment control, and evaluation.
Conclusion: In practice, nurses followed the guideline to a high degree. Systolic blood pressure, pulse rate, body temperature, and oxygen saturation were improved factors after implementation of the clinical nursing practice guideline for multiple injury patients.

Keywords: Clinical nursing practice guideline, Multiple injury patients, Nursing outcomes