Objectives: To study the urinary symptoms and quality of life changes in Thai women with overactive bladder (OAB) after tolterodine treatment.
Material and Method: Thirty women (aged 30-77 years) diagnosed as having OAB at the Gynecology Clinic, King Chulalongkorn Memorial Hospital from January to April 2004 were included in the present study. Tolterodine 2 mg, twice daily was given. After 8 weeks treatment, changes in micturition diary variables and tolerability were determined. Short form 36 (SF36) questionaires (Thai version) were given before and after 8 weeks of treatment.
Results: At 8 weeks, all micturition per day decreased from 16.7 + 5.3 to 6.7 + 2.4 times per day. The number of nocturia episodes decreased from 5.4 + 4.2 to 1.1 + 1.0 times per night. The most common side effect was dry month in 5 cases (16.7%) with 2 cases reporting a moderate degree and 1 case with severe degree. Only one case (3.3%) withdrew from the present study due to a severe dry mouth. The SF-36 scores changed significantly in the domains of physical functioning, role function emotional, social function and mental heath.
Conclusion: Tolterodine was well tolerated and its effects improved the quality of life in Thai women with OAB.

Keywords: Tolterodine, Overactive bladder, Quality of life