J Med Assoc Thai 2009; 92 (12):128

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Assessment of Nicotine Dermal Contact and Urinary Cotinine of Tobacco Processing Workers
Kongtip P Mail, Trikunakornwong A , Chantanakul S , Yoosook W , Loosereewanich P , Rojanavipart P

Objective: To assess the dermal contact of nicotine dust, subjective symptoms and urinary cotinine of post
curing tobacco workers.

Material and Method:
Dermal hand wipes of residual nicotine dust samples, morning urine samples and
subjective symptoms were collected from 30 workers. The hand-wipe samples and urine samples were analyzed
for nicotine and cotinine by a GC/MS, respectively.

Results: The average amount of nicotine on the hands of workers was 0.24 microgram/cm2, while the average
urinary cotinine concentration of workers was 3.08 microgram/ml. Moreover, there was a significant
correlation between nicotine residue on hands and urinary cotinine excretion at r = 0.978, p < 0.05. There
was also a significant relationship between the occupational related nicotine residue on hands and the
number of subjective symptoms reported (p < 0.05).

Conclusion: The nicotine residue on hands could be used as an indicator of occupational nicotine dust
exposure which might affect the health of tobacco workers.

Nicotine, Cotinine, Tobacco dust, GC/MS

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