Rosai-Dorfman disease (RDD) manifesting as a solitary osseous lesion especially of talus bone is rare. The authors reported a 31-year-old Thai man who had chronic left ankle pain and the biopsy of his talar lesion demonstrated emperipolesis, the typical histological feature of RDD. He was treated with curettage and adjuvant bisphosphonate and appeared to show improvement in clinical symptoms and radiological evidence. To the authors’ knowledge, this is the first report of an intraosseous RDD lesion treated with bisphosphonate with imaging follow-up.

Keywords: Rosai-Dorfman disease; Talus; Solitary; Radiology; Bisphosphonate

DOI: doi.org/10.35755/jmedassocthai.2021.12.13087

Received 14 June 2021 | Revised 9 November 2021 | Accepted 12 November 2021