The authors reported a 54 year-old Italian woman with headache attributed to spontaneous low cerebrospinal pressure and normal brain magnetic resonance imaging. Lumbar puncture was done and opening pressure was not measurable. 99mTc radionuclide cysternography was used in diagnosis and demonstrated 3 lumbar leakages and early appearance of bladder activity. Epidural blood patch was performed. This option was safe and successful to treat this kind of headache without relapse of symptoms after 3 years follow-up.

Keywords: Headache, Radionuclide cysternography, Epidural blood patch