Streptococcus pneumoniae is a rarely recognized cause of neonatal sepsis. We report invasive pneumococcal
infection in three neonates. The infections were abrupt, severe, and rapidly progressive in two neonates with fatal outcome
despite antibiotic therapy. There was no identifiable risk factor. Maternal colonization should be further studied.

Keywords: Invasive pneumococcal disease, S. pneumoniae, Neonates