A study of 109 female volunteers in good health and reproductive life,the mean age was 38.5 years,the volunteers had no intake of any kind of medicine before blood examination. The mean value of PINP is 44.57 ng/ml, standard deviation=19.91,standard error=1.9 with 95% confident interval = 40.79 to 48.35 ng/ml The PINP is a bone formation marker which is secreted by osteoblast ,the advantage of the present study was helping the evaluation of bone status after bone forming agents therapy. In addition PINP showed the status of bone turnover when compared to bone resorption marker(CTx).

Keywords: PINP, Procollagen type 1 nitrogenous propeptides