Objectives: To compare the performance of various prediction equations for creatinine clearance (CrCl) and glomerular filtration rate (GFR) estimation in healthy Thai adults.
Material and Method: 60 healthy adults had urine analysis, serum creatinine and 24-hour urinary creatinine assessment. The author compared Cockcroft-Gault (CG), MDRD, and Rule equations, and that using urine-CrCl for estimation of GFR.
Results: The urine-CrCl was 105.3 39.3 ml/min/1.73 m2. The CrCl/GFR using CG and MDRD equations were significantly lower than urine-CrCl. There was considerable difference between the stratification of renal function with the various formulae. According to both equations, the incidence of subjects with CrCl/GFR of < 90 ml/min/1.73 m2 was about 60%. R2 reflecting the degree of correlation between estimated CrCl/GFR and the urine-CrCl was weak.
Conclusion: The performance of the CG and MDRD equations were suboptimal for renal function assessment in Thai healthy adults. Further research is required to develop more reliable methods for estimating GFR across different ethic groups.

Keywords: Glomerular filtration rate, Creatinine clearance, Prediction equations, Normal healthy Thai adults,
Cockcroft-Gault equation, MDRD equation