Objective: To study lipid profile of menopausal women with hormone therapy.
Material and Method: Two hundred and sixty eight menopausal women in good health conditions, separated into natural and surgical menopause group, received service at Menopausal clinic in Srinagarind Hospital, Faculty of Medicine, Khon Kaen University since 1996-2004. They regularly took a single type of hormone therapy for about 12 months and obtained blood cholesterol levels for pre- and post-hormone therapy of about 12 months period. The data were analyzed with SPSS v. 10.0.5.
Results: The average age of the sample groups were 50.91 + 5.93 years and 52.83 + 5.28 respectively. Both sample groups have similar mean level of cholesterol levels during pretreatment period. Surgical menopausal group has greater HDL level than the naturally menopausal group with the average level of 64.24 + 15.32 mg/dl. and 58.80 + 17.20 mg/dl. respectively. However, after taking hormone therapy, blood cholesterol level was significantly changed in both groups. The mean level of LDL decreased ( 8.59% and 11.49% respectively) and mean level of HDL increased (15.43% and 6.89% respectively).
Conclusions: Hormone therapy in menopausal women can improve cholesterol levels by decreasing LDL and increasing HDL with statistical significance (p < 0.05).

Keywords: Menopause, Hormone therapy, Lipid profile