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Original ArticleOpen Access
Prevalence of Aspirin Resistance in Stroke Patients in Phramongkutklao Hospital
Nidhinandana S 
,
Changchit S
,
Changchit S Objective: To study the prevalence of aspirin resistance in cerebrovascular disease patients in Phramongutklao hospital .
Material and Method: The acute ischemic and stable stroke patients who received aspirin at least 60 mg, at least 7 days and
the last dose of aspirin at least 24 hours before blood test for platelet aggregation. ADP and Collagen were used as platelet
aggregator.
Results : During July 2007- December 2008 , 141 cases of ischemic stroke were enrolled. “Aspirin resistant” was defined as
mean aggregation more than 60% both ADP and Collagen. “Aspirin semi-responder” was mean aggregation less than 60%
for ADP or Collagen.
Conclusion: Prevalence of aspirin resistance in Phramonkutklao hospital is 56 % (79/141), and there are relationship
between aspirin resistance and timing in the first episode of stroke.
Keywords: Aspirin resistance, Ischemic stroke
Material and Method: The acute ischemic and stable stroke patients who received aspirin at least 60 mg, at least 7 days and
the last dose of aspirin at least 24 hours before blood test for platelet aggregation. ADP and Collagen were used as platelet
aggregator.
Results : During July 2007- December 2008 , 141 cases of ischemic stroke were enrolled. “Aspirin resistant” was defined as
mean aggregation more than 60% both ADP and Collagen. “Aspirin semi-responder” was mean aggregation less than 60%
for ADP or Collagen.
Conclusion: Prevalence of aspirin resistance in Phramonkutklao hospital is 56 % (79/141), and there are relationship
between aspirin resistance and timing in the first episode of stroke.
Keywords: Aspirin resistance, Ischemic stroke
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