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Original ArticleOpen Access
Orthostatic hypotension: a non-motor complication assessment in 82 patients with idiopathic Parkinson’s disease in Phramongkutklao Hospital
Sithinamsuwan P 
,
Orrawanhanothai P ,
Thithum K ,
Udommongkol C ,
Chairangsaris P ,
Chinvarun Y ,
Wongmek W ,
Suphakasem S ,
Suwantamee J
,
Orrawanhanothai P ,
Thithum K ,
Udommongkol C ,
Chairangsaris P ,
Chinvarun Y ,
Wongmek W ,
Suphakasem S ,
Suwantamee J Objective: Parkinson’s disease (PD) is one of the neurogenic etiologies of orthostatic hypotension, a non-motor symptoms
complex, that tends to be under-recognized and under-treated leading to a major cause of disability for PD patients. This
complication is associated with one or recurrent falls causing mortality and morbidity. To the authors’ knowledge, there is no
study about this condition in Thai PD population. The authors therefore aimed to determine the frequency, clinical and risk
factors of orthostatic hypotension in PD patients treated in Phramongkutklao Hospital.
Material and Method: The authors enrolled consecutive patients with idiopathic PD over a 10-month period. Supine and
standing blood pressure (BP) were measured sequentially as the standard techniques. Orthostatic hypotension (OH) was
diagnosed if there was a reduction in systolic or diastolic BP of at least 20 or 10 mmHg respectively within 3 minutes after
standing. The authors analyzed for the frequency of this condition as well as determined the risk factors between the OH and
non-OH groups.
Results: The number of patients enrolled was 82 with the mean age of 69 years. The median duration of PD was 4 years.
Eighty-five percent were in Hoehn & Yahr stage 1-3. Thirty-three patients (40.2%) had orthostatic hypotension and 70% of
them were asymptomatic. By univariate and multivariate analysis, the risk factors for this condition were the longer duration
of PD diagnosis, the more advanced staging and the use of selegiline.
Conclusions: The frequency of orthostatic hypotension among the present PD was 40.2%. The longer duration of disease, the
more advanced stage of Parkinson’s disease and selegiline usage were the factors associated with this non-motor condition.
Keywords: Orthostatic hypotension, Parkinson’s disease, Non-motor complication
complex, that tends to be under-recognized and under-treated leading to a major cause of disability for PD patients. This
complication is associated with one or recurrent falls causing mortality and morbidity. To the authors’ knowledge, there is no
study about this condition in Thai PD population. The authors therefore aimed to determine the frequency, clinical and risk
factors of orthostatic hypotension in PD patients treated in Phramongkutklao Hospital.
Material and Method: The authors enrolled consecutive patients with idiopathic PD over a 10-month period. Supine and
standing blood pressure (BP) were measured sequentially as the standard techniques. Orthostatic hypotension (OH) was
diagnosed if there was a reduction in systolic or diastolic BP of at least 20 or 10 mmHg respectively within 3 minutes after
standing. The authors analyzed for the frequency of this condition as well as determined the risk factors between the OH and
non-OH groups.
Results: The number of patients enrolled was 82 with the mean age of 69 years. The median duration of PD was 4 years.
Eighty-five percent were in Hoehn & Yahr stage 1-3. Thirty-three patients (40.2%) had orthostatic hypotension and 70% of
them were asymptomatic. By univariate and multivariate analysis, the risk factors for this condition were the longer duration
of PD diagnosis, the more advanced staging and the use of selegiline.
Conclusions: The frequency of orthostatic hypotension among the present PD was 40.2%. The longer duration of disease, the
more advanced stage of Parkinson’s disease and selegiline usage were the factors associated with this non-motor condition.
Keywords: Orthostatic hypotension, Parkinson’s disease, Non-motor complication
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