Views: 1,614 | Downloads:
218
| Responses: 0
XML | Respond to this article | Alert & updates | Request permissions | Email to a friend |
Original ArticleOpen Access
Anti-Inflammatory, Anti-Nociceptive and Antipyretic Effects of the Ethanol Extract From Root of Piper Sarmentosum Roxb.
Background: Piper sarmentosum Roxb. (Cha Phul) is a plant in the Piperaceae family which the whole plant is used as an
expectorant and the leaf as a carminative. Many extracts from the plants in this family show anti-nociceptive, anti-inflammatory
and antipyretic activities in various animal models.
Objective: To investigate the anti-inflammatory, anti-nociceptive and antipyretic effects of the ethanol extract from P. sarmentosum
root.
Material and Method: In vivo study.
Results: P. sarmentosum extract significantly inhibited ethyl phenylpropiolate-induced ear edema as well as carrageenaninduced
hind paw edema in rats. The extract reduced transudative and granuloma weights of the chronic inflammatory model
using the cotton pellet-induced granuloma formation in rats. The extract exerted a pronounced inhibitory activity on the early
phase and late phase of the formalin test in mice. In addition, the extract elicited an antipyretic activity on yeast-induced
hyperthermia in rats.
Conclusion: P. sarmentosum extract possessed anti-inflammatory, anti-nociceptive and antipyretic activities.
Keywords : Piper sarmentosum, Anti-inflammatory, Anti-nociceptive, Antipyretic
expectorant and the leaf as a carminative. Many extracts from the plants in this family show anti-nociceptive, anti-inflammatory
and antipyretic activities in various animal models.
Objective: To investigate the anti-inflammatory, anti-nociceptive and antipyretic effects of the ethanol extract from P. sarmentosum
root.
Material and Method: In vivo study.
Results: P. sarmentosum extract significantly inhibited ethyl phenylpropiolate-induced ear edema as well as carrageenaninduced
hind paw edema in rats. The extract reduced transudative and granuloma weights of the chronic inflammatory model
using the cotton pellet-induced granuloma formation in rats. The extract exerted a pronounced inhibitory activity on the early
phase and late phase of the formalin test in mice. In addition, the extract elicited an antipyretic activity on yeast-induced
hyperthermia in rats.
Conclusion: P. sarmentosum extract possessed anti-inflammatory, anti-nociceptive and antipyretic activities.
Keywords : Piper sarmentosum, Anti-inflammatory, Anti-nociceptive, Antipyretic
Download:
PDF