J Med Assoc Thai 2010; 93 (12):1

Views: 1,277 | Downloads: 212 | Responses: 0

PDF XML Respond to this article Print Alert & updates Request permissions Email to a friend


Anti-Inflammatory, Anti-Nociceptive and Antipyretic Effects of the Ethanol Extract From Root of Piper Sarmentosum Roxb.
Sireeratawong S Mail, Vannasiri S , Sritiwong S , Itharat A , Jaijoy K

Background: Piper sarmentosum Roxb. (Cha Phul) is a plant in the Piperaceae family which the whole plant is used as an
expectorant and the leaf as a carminative. Many extracts from the plants in this family show anti-nociceptive, anti-inflammatory
and antipyretic activities in various animal models.

Objective: To investigate the anti-inflammatory, anti-nociceptive and antipyretic effects of the ethanol extract from P. sarmentosum
root.

Material and Method: In vivo study.

Results: P. sarmentosum extract significantly inhibited ethyl phenylpropiolate-induced ear edema as well as carrageenaninduced
hind paw edema in rats. The extract reduced transudative and granuloma weights of the chronic inflammatory model
using the cotton pellet-induced granuloma formation in rats. The extract exerted a pronounced inhibitory activity on the early
phase and late phase of the formalin test in mice. In addition, the extract elicited an antipyretic activity on yeast-induced
hyperthermia in rats.

Conclusion:
P. sarmentosum extract possessed anti-inflammatory, anti-nociceptive and antipyretic activities.

Keywords :
Piper sarmentosum, Anti-inflammatory, Anti-nociceptive, Antipyretic

Download: PDF