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Original ArticleOpen Access
The Efficacy and Side Effects of Oral Centella asiatica extract for Wound Healing Promotion in Diabetic Wound Patients
Paocharoen V 
Objective: To study clinical efficacy and side effects of the oral Centella asiatica extract capsule in the diabetic wound healing.
And to study the side effects of Centella asiatica extract capsule.
Material and Method: This prospective randomized control study enrolled two hundred diabetic patients in the department
of Surgery, Thammasat University Hospital. The exclusion criterion were low immune patients, oral steroid intake, age more
than 80 year and less than 18 yeas, serum albumin less than 3.0 gm/dl, uncorrected peripheral arterial diseased patients, and
uncontrolled infective wound. The termination criterion were patient refusal, wound infection, delayed primary sutured
wound, secondary healing wound. The patients were divided into two groups randomly, group A was Centella asiatica extract
capsule group and group B was placebo group. Centella asiatica extract capsule and placebo were prescribed in each group
under the random sheet. The administration was 2 capsules after meal, three times a day (50 mg of extracted asiaticoside /
capsule in group A). The general symptoms, wound characteristics, wound size and depth were examined at day 7, day14 and
day 21 by the same investigator. The demographic data of the sample were analyzed by student t test and comparative wound
characteristics were analyzed by Pearson Chi-Square test.
Results: Wound contraction in the study group is better than placebo group but granulation tissue forming is better in the
placebo group. No serious adverse reaction in both groups.
Conclusion: Centella asiatica extract capsule is the Thai herb preparation capsule that effective in the wound healing
promotion and also suppress the scar in diabetic wound patients. There was no demonstrable serious side effect of the
Centella asiatica extract capsule group. Centella asiatica extract capsule can shorten the course of diabetic wound and can
be prescribed to the diabetic patients safely.
Keywords: Centella asiatica, Wound healing, Diabetic wound
And to study the side effects of Centella asiatica extract capsule.
Material and Method: This prospective randomized control study enrolled two hundred diabetic patients in the department
of Surgery, Thammasat University Hospital. The exclusion criterion were low immune patients, oral steroid intake, age more
than 80 year and less than 18 yeas, serum albumin less than 3.0 gm/dl, uncorrected peripheral arterial diseased patients, and
uncontrolled infective wound. The termination criterion were patient refusal, wound infection, delayed primary sutured
wound, secondary healing wound. The patients were divided into two groups randomly, group A was Centella asiatica extract
capsule group and group B was placebo group. Centella asiatica extract capsule and placebo were prescribed in each group
under the random sheet. The administration was 2 capsules after meal, three times a day (50 mg of extracted asiaticoside /
capsule in group A). The general symptoms, wound characteristics, wound size and depth were examined at day 7, day14 and
day 21 by the same investigator. The demographic data of the sample were analyzed by student t test and comparative wound
characteristics were analyzed by Pearson Chi-Square test.
Results: Wound contraction in the study group is better than placebo group but granulation tissue forming is better in the
placebo group. No serious adverse reaction in both groups.
Conclusion: Centella asiatica extract capsule is the Thai herb preparation capsule that effective in the wound healing
promotion and also suppress the scar in diabetic wound patients. There was no demonstrable serious side effect of the
Centella asiatica extract capsule group. Centella asiatica extract capsule can shorten the course of diabetic wound and can
be prescribed to the diabetic patients safely.
Keywords: Centella asiatica, Wound healing, Diabetic wound
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