J Med Assoc Thai 2011; 94 (3):94

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A Retrospective Study Comparing Hypofractionated Radiotherapy and Conventional Radiotherapy in Postmastectomy Breast Cancer
Pinitpatcharalert A Mail, Chitapanarux I , Euathrongchit J , Tharavichitkul E , Sukthomya V , Lorvidhaya V

Background: The conventional radiotherapy (CRT) in postmastectomy breast cancer is 1.8-2.0 Gy daily for 25 fractions,
while hypofractionated radiotherapy (HFRT) delivered dose in fewer fractions with larger radiation intensity. The present
study compares the efficacy of HFRT and CRT.

Material and Method: From 2004 to 2006, 215 patients were retrospectively reviewed. Sixty seven patients received CRT
and 148 patients received HFRT (2.65 Gy in 16-18 fractions). Five-year locoregional control (LRC), disease free survival
(DFS), overall survival (OS) and toxicities were analyzed.

Results: Median follow-up was 39 months. Five-year LRC was 86.6% in CRT and 85.8% in HFRT (p = 0.852). Five-year
DFS was 62.7% and 69.6% (p = 0.136) in CRT and HFRT, respectively. Patients who received HFRT had significant increase
in 5-year OS (62.7% and 73.0% (p = 0.048). No difference of toxicities including changes in chest wall appearance, skin
fibrosis, brachial plexopathy, arm edema, pulmonary fibrosis, rib fractures and cardiovascular events was found between
two groups.

HFRT is as effective as CRT in postmastectomy breast cancer.

Keywords: Breast cancer, Hypofractionation, Radiotherapy, Postmastectomy

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