J Med Assoc Thai 2011; 94 (2):111

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Nephrotic Syndrome in Elderly Patients: Three Years Experience at Siriraj Hospital
Jiratthawong M Mail, Vongwiwatana A , Vareesangthip K , Vasuvattakul S , Chanchairujira T , Teerapornlertratt T , Parichatikanond P , Choensuchon B

Background: The population age is being high and nephotic syndrome is a common renal disease.

Objective:
To find the etiology and clinical manifestations of nephrotic syndrome in the elderly patients who underwent renal
biopsy at Siriraj hospital including management and outcome.

Material and Method: Retrospective study in 76 nephrotic patients whose age > 50 years and underwent renal biopsy
between 2005-2007.

Results: Seventy six nephrotic patients with age ranged from 50-84 years were analysed. Primary glomerulonephritis
diseases were found more than secondary causes (5:2). The two most common glomerulonephritis were membranous GN
and focal/segmental glomerulosclerosis. The etiology of common secondary GN was lupus nephtitis 11.84% following by
diabetic nephropathy and amyloidosis. The patients received immunosuppressive drugs and complete response was found in
51%, partial response 10.2%, no response was 2% and no immunosuppressive therapy 36.7%. There was 1 patient died of
septicaemia.

Conclusion:
Nephrotic syndrome in the elderly patients were not uncommon. The causes should be identified for prompt
management and excellent outcome.

Keywords:
Nephrotic syndrome, Renal biopsy, Elderly

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