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Original ArticleOpen Access
A Randomized, Prospective, Double-Blind Study of the Efficacy of Dexpanthenol Nasal Spray on the Postoperative Treatment of Patients with Chronic Rhinosinusitis after Endoscopic Sinus Surgery
Tantilipikorn P 
,
Tunsuriyawong P ,
Jareoncharsri P ,
Bedavanija A ,
Assanasen P ,
Bunnag C ,
Metheetrairut C
,
Tunsuriyawong P ,
Jareoncharsri P ,
Bedavanija A ,
Assanasen P ,
Bunnag C ,
Metheetrairut C Objective: To assess the efficacy of dexpanthenol nasal spray compared with normal saline spray in the postoperative
treatment of patients with chronic rhinosinusitis (CRS) who underwent endoscopic sinus surgery (ESS).
Materials and Method: A prospective, randomized controlled study was conducted in CRS patients who underwent ESS. The
enrolled patients had never been operated intranasally. These patients received either dexpanthenol or normal saline nasal
spray intranasally four times a day for six weeks post-operatively.
Results: Fifty CRS patients were recruited in the present study. Age ranged from 23 to 63 years (means 43.4 + 11.2 years).
Forty-four percent of patients were diagnosed as CRS without nasal polyps (NP) (CRSs NP) and 56% were CRS with NP
(CRSw NP). Twenty-five cases were randomly assigned to use dexpanthenol nasal spray whereas the other 25 cases used
normal saline nasal spray. The preoperative severity of CRS, determined by the computerized tomography (CT) scan scoring
system of Lund-McKay was 13.9 + 6.2 in the dexpanthenol group and 13.6 + 6.9 in the normal saline group, which were not
statistically different (p > 0.05). The endoscopic scoring was 10.2 + 2 in the dexpanthenol group and 10.7 + 3 in the normal
saline group, which were not statistically different (p > 0.05). The mucociliary transit time improvement (time difference
between pre- and post-treatment by nasal spray) was 8.4 + 3.3 minutes in the dexpanthenol group and 1.7 + 1.2 minutes in
the normal saline group, which were statistically different (p < 0.05).
Conclusion: The majority of the postoperative symptom scores and all of the endoscopic scores of the dexpanthenol group
were not statistically different from those of the normal saline group. However, dexpanthenol nasal spray has superior
efficacy compared with normal saline nasal spray on improvement of mucociliary clearance and nasal discharge in the
postoperative care of CRS patients after ESS.
Keywords: Rhinosinusitis, Nasal spray, Endoscopic sinus surgery
treatment of patients with chronic rhinosinusitis (CRS) who underwent endoscopic sinus surgery (ESS).
Materials and Method: A prospective, randomized controlled study was conducted in CRS patients who underwent ESS. The
enrolled patients had never been operated intranasally. These patients received either dexpanthenol or normal saline nasal
spray intranasally four times a day for six weeks post-operatively.
Results: Fifty CRS patients were recruited in the present study. Age ranged from 23 to 63 years (means 43.4 + 11.2 years).
Forty-four percent of patients were diagnosed as CRS without nasal polyps (NP) (CRSs NP) and 56% were CRS with NP
(CRSw NP). Twenty-five cases were randomly assigned to use dexpanthenol nasal spray whereas the other 25 cases used
normal saline nasal spray. The preoperative severity of CRS, determined by the computerized tomography (CT) scan scoring
system of Lund-McKay was 13.9 + 6.2 in the dexpanthenol group and 13.6 + 6.9 in the normal saline group, which were not
statistically different (p > 0.05). The endoscopic scoring was 10.2 + 2 in the dexpanthenol group and 10.7 + 3 in the normal
saline group, which were not statistically different (p > 0.05). The mucociliary transit time improvement (time difference
between pre- and post-treatment by nasal spray) was 8.4 + 3.3 minutes in the dexpanthenol group and 1.7 + 1.2 minutes in
the normal saline group, which were statistically different (p < 0.05).
Conclusion: The majority of the postoperative symptom scores and all of the endoscopic scores of the dexpanthenol group
were not statistically different from those of the normal saline group. However, dexpanthenol nasal spray has superior
efficacy compared with normal saline nasal spray on improvement of mucociliary clearance and nasal discharge in the
postoperative care of CRS patients after ESS.
Keywords: Rhinosinusitis, Nasal spray, Endoscopic sinus surgery
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| Related Correction: | CORRECTION (Vol 96, No 8: AUGUST 2013) |