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Original ArticleOpen Access
Dynamic Contrasted MR Imaging in Differentiation of Recurrent Malignant Soft Tissue Tumor from Posttreatment Changes
Jaovisidha S 
,
Traiporndeeprasert P ,
Chitrapazt N ,
Thakkinstian A ,
Nartthanarung A ,
Subhadrabandhu T ,
Siriwongpairat P
,
Traiporndeeprasert P ,
Chitrapazt N ,
Thakkinstian A ,
Nartthanarung A ,
Subhadrabandhu T ,
Siriwongpairat P Objective: To investigate dynamic contrast enhanced magnetic resonance imaging (DCE-MRI) in term of differentiationrecurrent malignant soft tissue tumor (MSTT) from post-treatment changes.
Material and Method: DCE-MRI was performed in consecutive patients in two-year periods to differentiate recurrent MSTTfrom post-treatment (surgery, radiotherapy, chemotherapy) changes. The steepest slope (SS) ratio between the artery and thelesion, sensitivity, and specificity were calculated.
Results: Thirty-five DCE-MRI studies were performed in 30 patients, which included 14 males and 16 females with an agerange from 12 to 71 years (median 45.81 year). Thirteen were with recurrence and 22 were with post-treatment changes. TheSS ratios were ranged from 0.66 to 29.15. The lesions with the SS ratio > 9.28 were all benign at follow up of at least twomonths, whereas those with SS ratio < 1.05 were all recurrent tumors proven by biopsy or surgery. Overlapping occurredwhen the SS ratios > 1.05 but < 9.28 in which the recurrence was 42.31%. The chance of having recurrence rather thanpost-treatment changes was approximately two and five times in patients with the ratio of 5.07 and 1.55, with the specificity of54.55% and 90.91%, respectively.
Conclusion: The SS ratio between the artery and the lesion has limitations to differentiate recurrent MSTT from posttreatmentchanges. It is useful when the ratio is less than 1.05 (malignant) or more than 9.28 (benign). The chance of havingrecurrence rather than post-treatment changes was approximately two and five times in patients with the ratio of 5.07 and1.55, respectively. The less value the ratio is, the more possibility to be recurrent tumor.
Keywords: Magnetic resonance (MR), Dynamic, Dynamic contrasted, Malignant, Soft tissue tumor, Recurrent
Material and Method: DCE-MRI was performed in consecutive patients in two-year periods to differentiate recurrent MSTTfrom post-treatment (surgery, radiotherapy, chemotherapy) changes. The steepest slope (SS) ratio between the artery and thelesion, sensitivity, and specificity were calculated.
Results: Thirty-five DCE-MRI studies were performed in 30 patients, which included 14 males and 16 females with an agerange from 12 to 71 years (median 45.81 year). Thirteen were with recurrence and 22 were with post-treatment changes. TheSS ratios were ranged from 0.66 to 29.15. The lesions with the SS ratio > 9.28 were all benign at follow up of at least twomonths, whereas those with SS ratio < 1.05 were all recurrent tumors proven by biopsy or surgery. Overlapping occurredwhen the SS ratios > 1.05 but < 9.28 in which the recurrence was 42.31%. The chance of having recurrence rather thanpost-treatment changes was approximately two and five times in patients with the ratio of 5.07 and 1.55, with the specificity of54.55% and 90.91%, respectively.
Conclusion: The SS ratio between the artery and the lesion has limitations to differentiate recurrent MSTT from posttreatmentchanges. It is useful when the ratio is less than 1.05 (malignant) or more than 9.28 (benign). The chance of havingrecurrence rather than post-treatment changes was approximately two and five times in patients with the ratio of 5.07 and1.55, respectively. The less value the ratio is, the more possibility to be recurrent tumor.
Keywords: Magnetic resonance (MR), Dynamic, Dynamic contrasted, Malignant, Soft tissue tumor, Recurrent
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