A 62 year–old Thai man presented symptoms of chronic progressive headache for nearly one year and left side ataxia for two weeks. MRI brain suggested a primary malignant brain tumor with moderate hydrocephalus. Total removal of the lesion was performed. The histopathological report was caseating granulomatous inflammation involving cerebellar parenchyma; suggestive of tuberculoma, PCR for M. Tuberculosis complex, using brain tissue from formalin-fixed paraffinembeded block, yields positive result for M. Tuberculosis complex. He was treated with antituberculous drugs.

Keywords: Cerebral tuberculoma, CNSTs, Tubercular, Primary brain tumor