Material and Method: Between January 2007 and September 2010, TRUS fi ndings and clinical outcomes of 16 from 226 subjects were studied. The demographic data, ultrasound parameters as prostate volume and vascularity, and clinical parameters were evaluated. Correlation between ultrasound and clinical parameters were analyzed using Pearson correlation analysis.

Results: During mean time follow-up of 6.48 months, the volume of the central gland (CG) signifi cantly increased (p = 0.02), the volume of the total gland (TG) increased, and the volume of the peripheral zone (PZ) slightly decreased. The vascularity of the TG, CG, and PZ were signifi cantly increased. The periurethral region vascularity was not significantly increased (p = 0.06), whereas total serum testosterone, prostate specifi c antigen (PSA), and PSA density were increased. The International Prostate Symptom Score (IPSS) was signifi cantly decreased (p < 0.001). There was a signifi cant correlation between increased prostate volume and increased serum PSA.

Conclusion: Testosterone supplementation in LOH men was found to cause an increase in TG volume during the first six months. The preferentially increased CG volume and prostatic vascularity might be due to exogenous testosterone. The authors observed a signifi cantly increased PSA with a strong correlation between serum PSA and prostate volume.

Keywords: Prostate, Transrectal ultrasound, Late onset hypogonadism, Testosterone supplementation