Material and Method: One hundred forty eight patients with drug resistant TLE who had magnetic resonance imaging (MRI) that demonstrated unilateral HS underwent temporal lobectomy between 2004 and 2008 by a single neurosurgeon. All patients had completed at least two years of follow-up. Seizure outcome was categorized into seizure-free and not seizure-free.

Results: Ninety-five patients (64.2%) were seizure-free after surgery at two years of follow-up. At four years follow-up, 47 patients (77.1%) were seizure-free for at least two years. There was no operative mortality or significant morbidity. No clinical variables are predictive of surgical outcomes at two and four years of follow-up.

Conclusion: Temporal lobectomy for drug-resistant TLE with HS is safe and effective. The authors did not identify predictive factors of surgical outcomes in TLE-HS.

Keywords: Hippocampal sclerosis, Temporal lobe epilepsy, Drug resistant epilepsy surgery, Temporal lobectomy, Outcome, Predictors