J Med Assoc Thai 2010; 93 (11):1321

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Granulomatous Mycosis Fungoides with Large Cell Transformation Misdiagnosed as Leprosy
Siriphukpong S Mail, Pattanaprichakul P , Sitthinamsuwan P , Karoopongse E

Background: Granulomatous mycosis fungoides is an unusual histopathological variant of cutaneous T-cell lymphoma
without clinical distinction from classic mycosis fungoides. Symptoms associated with peripheral nerve involvement have
rarely been reported in the literature.

Case Report: The authors described a case of granulomatous MF stage IIB with large cell transformation who initially
presented with leprosy-like condition and chronic left peroneal neuropathy. The patient received six courses of gemcitabine
with greater than 90% improvement of skin lesions. The rest of the lesions were successfully treated with local electron beam
radiation.

Conclusion: Granulomatous MF with neuropathy can be clinically misdiagnosed if there is no histopathological and
immunohistochemical finding to support the diagnosis of lymphoma.

Keywords: Granulomatous mycosis fungoides, Large cell transformation, Granuloma annulare-like, Leprosy

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