Brunner’s gland hamartomas are uncommon benign tumor of the duodenum. Most lesions are small and
asymptomatic. Occasionally, those lesions may be large and manifest as a rare cause of upper GI hemorrhage or duodenal
obstruction.

The authors report here two cases of Brunner’s gland hamartoma presenting with upper GI hemorrhage that were
not amenable to endoscopic polypectomy thus requiring surgical resection.
The literature on Brunner’s gland hamartoma was reviewed.

Keywords: Upper GI hemorrhage, Brunner’s gland hamartoma, Surgical resection, Gastroduodenoscopy