Objective: To study the demography, causative drugs, laboratory features, treatments, complications, and mortality of TEN/SJS in Chonburi Hospital and compare factors associated with mortality between groups.

Material and Method: The medical records of TEN/SJS patients between 2005 and 2009 were retrospectively reviewed. Characteristics of the patients and factors associated with mortality were analyzed by SPSS version 19 for windows.

Results: There were 15 SJS and 9 TEN patients. The average age was 40.13±22 years. Male to female ratio was 1.4:1. The mean SCORTEN on day 1 was 1.54±1.1 and 1.79±1.59 on day 3. The overall mortality was 20.83%. Antibiotics were the commonest group of drugs causing TEN (55.6%) and SJS (66.7%). Septicemia and pulmonary infections were associated with higher mortality (p<0.001 and 0.004 respectively). Steroid treatment was associated with lower mortality 13.33% vs. 33.33%.

Conclusion: Antibiotics are the most common causative agents in SJS/TEN. Sepsis and pulmonary infections are associated with higher mortality. Steroid treatment may have some survival benefit.

Keywords: Stevens-Johnson syndrome, Toxic epidermal necrolysis