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Material and Method: This is a retrospective cohort study. Patient’s medical records with the diagnosis of CHF between January 2008 and December 2009 were reviewed. The authors divided patients with CHF into two groups according to history of NSAIDs-exposure within a one year prior to admission. Baseline characteristics were compared and Kaplan-Meier analysis was used to determine survival difference.
Results: One hundred ninety six CHF patients were included in the present study. NSAIDs-used within one year was confirmed in 47 patients (23.9%). Most of baseline characteristics were comparable for both groups. The major precipitating cause of CHF in NSAIDs-exposed group was statistically significant for acute coronary syndrome (40.4% vs. 14.8%, p-value <0.001), whereas anemia and renal failure failed to show statistical significance with p-value 0.859 and 0.370, respectively. Overall mortality showed no difference in both groups with p-value of 0.639.
Conclusion: Previous studies considered NSAIDs to be associated with CHF due to salt and water retention. However, in the Thai population, there was an increasing incidence of acute coronary syndrome in concomitant with decompensated CHF. Overall mortality in both groups was not significantly different.
Keywords: Congestive heart failure, Decompensated heart failure, Non-steroidal anti-inflammatory drugs, NSAIDs, NSAIDs-related heart failure, Acute coronary syndrome, Heart failure precipitating factors, Thai