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Material and Method: The authors studied the levels of biochemical markers of thrombin generation (thrombin-anti-thrombin [TAT] complex, fibrinogen, and factor XIII) and fibrinolysis (D-dimer) in specimens of blood from the atria in 35 consecutive patients with moderate to severe MS (18 in sinus rhythm and 17 in AF) who underwent percutaneous balloon mitral valvotomy.
Results: The levels coagulation factors in left atrium in patients with MS in SR and AF were thrombin-anti-thrombin complex = 77.21±8.87 mg/L vs. 73.48±7.78 mg/L, p = 0.755, fibrinogen = 356.57±41.86 mg/L vs. 271.62±22.47 mg/L, p = 0.089, factor XIII = 139.88±8.96 mg/L vs. 123.42±6.24 mg/L, p = 0.152, and D-dimer = 846.14±137.84 mg/L vs. 693.88±164.67 mg/L, p = 0.481. Levels of coagulation activities did not correlate with the left atrial size.
Conclusion: This present study demonstrates that coagulation activity is not different whether they are in SR or in AF and suggests that anticoagulation therapy should be considered in these patients.
Keywords: Mitral stenosis, Coagulation activity, Sinus rhythm