Objectives: Measure the quality of life of middle-aged women with a disability and examine the association of their quality of life and socio-demographic factors.
Material and Method: A cross-sectional study was applied. Thirty-two women with disabilities aged 40 60 years were selected by using stratified random sampling. The WHOQOL-BREF-THAI, Modified Barthel ADL Index (BAI), Chula ADL Index (CAI), and Estrogen hormone deficit syndrome questionnaires were applied. Data were analyzed by using descriptive analysis and Spearman’s correlation.
Results: The level of their overall quality of life, when measuring all dimensions of WHOQOL, was moderate. Overall, QOL perceptions correlated positively and significantly with BAI (rs = 0.4848, p = 0.0048), CAI (rs = 0.5963, p = 0.0005), and their income balance (rs = 0.4124, p = 0.0150), while other factors such as marital status, educational level, occupation, duration of disability, disability level, health problem, and estrogen hormone deficit syndrome were not statistically significant correlated.
Conclusion: The present study results revealed that independency and financial sufficiency are significant factors on quality of life of disabled middle-age women. Promoting independency and financial status may be crucial for enhancing their quality of life.

Keywords: Quality of life, Disability, Middle-aged women, WHOQOL