J Med Assoc Thai 2007; 90 (7):1281

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Risk Assessment of Preeclampsia in Advanced Maternal Age by Uterine Arteries Doppler at 17-21 Weeks of Gestation
Sritippayawan S Mail, Phupong V

Objective: To assess the risk of preeclampsia development in elderly gravidarum by uterine arteries Doppler at 17-21 weeks’ gestation.
Material and Method: Pulsatility index (PI) of the uterine arteries was measured by color Doppler transabdominal sonography in 298 elderly gravida women at 17 – 21 weeks of gestation. The criterion for abnormal results was PI > 95th percentile of each gestational age and / or the presence of bilateral notches. The major end point was preeclampsia.
Results: Ten woman (3.4%) developed preeclampsia. Two hundred and eighty-four women (95.3%) had a normal Doppler flow of uterine arteries (PI < 95th percentile of each gestational age), and 14 woman (4.7%) had abnormal Doppler flow of uterine arteries. The sensitivity, specificity, and positive and negative predictive values for detecting preeclampsia were 20%, 95.8%, 14.3%, and 97.2%, respectively.
Conclusion: Women with mean PI > 95th of each gestational age have a high risk of developing preeclampsia. With the high negative predictive value, this test may be useful to minimize unnecessary interventions.

Keywords: Uterine artery, Doppler, Preeclampsia, Elderly gravidarum, Pulsatility index


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