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Original ArticleOpen Access
Insulin-Like Growth Factor-1 (IGF-1) Screening for the Diagnosis of Growth Hormone (GH) Deficiency
Sriphrapradang A 
,
Mahachoklertwattana P ,
Choubtum L ,
Preeyasombat C
,
Mahachoklertwattana P ,
Choubtum L ,
Preeyasombat C Growth hormone deficiency (GHD) is a common cause of growth retardation in children
and adolescents. Gold standard for the diagnosis of GHD is based upon two standard growth hormone
(GH) provocative tests demonstrating a peak serum GH of less than 7 ng/mL. These tests,
besides requiring multiple blood samplings, are time-consuming and costly. GH primarily mediates
its growth-promoting effect through insulin-like growth factor-! (IGF-1). Hence, basal serum IGF-1
level reflects GH status. We studied 47 prepubertal children with or without short stature. Aged
ranged between 4.3 and 15.6 years. They were divided into 2 groups based upon 2 standard GH
provocative tests. Seventeen children were classified as having GHD. The remaining 30 were nonGHD.
Basal serum IGF-1 was obtained before GH testing. The means±SE (range) of serum IGF-1
concentration were 44.26±3.19 (19.10-75.63) ng/mL in GHD and 118.42±10.03 (60.65-235.91)
ng/mL in non-GHD which were significantly different (P
and adolescents. Gold standard for the diagnosis of GHD is based upon two standard growth hormone
(GH) provocative tests demonstrating a peak serum GH of less than 7 ng/mL. These tests,
besides requiring multiple blood samplings, are time-consuming and costly. GH primarily mediates
its growth-promoting effect through insulin-like growth factor-! (IGF-1). Hence, basal serum IGF-1
level reflects GH status. We studied 47 prepubertal children with or without short stature. Aged
ranged between 4.3 and 15.6 years. They were divided into 2 groups based upon 2 standard GH
provocative tests. Seventeen children were classified as having GHD. The remaining 30 were nonGHD.
Basal serum IGF-1 was obtained before GH testing. The means±SE (range) of serum IGF-1
concentration were 44.26±3.19 (19.10-75.63) ng/mL in GHD and 118.42±10.03 (60.65-235.91)
ng/mL in non-GHD which were significantly different (P
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