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Case ReportOpen Access
Colchicine-Induced Myopathy in Renal Failure
Sinsawaiwong S 
,
Phanthumchinda K ,
Jongpiputvanich S
,
Phanthumchinda K ,
Jongpiputvanich S A 60 year-old woman with chronic renal failure developed acute proximal muscle weakness
after receiving a regular dosage of colchicine. Elevation of muscle enzymes and electromyography
were compatible with myopathy. Muscle biopsy revealed variation in muscle fiber size and
few vacuolated fibers which were features of colchicine-induced myopathy. The clinical improvement
and decreasing in muscle enzyme level occurred after colchicine withdrawal. Other potential
causes of myopathy such as chronic renal failure and other drugs were ruled out. We suggested
that colchicine should be used with caution in the presence of renal failure especially when other
drugs which affect the metabolism of colchicine are also prescribed.
after receiving a regular dosage of colchicine. Elevation of muscle enzymes and electromyography
were compatible with myopathy. Muscle biopsy revealed variation in muscle fiber size and
few vacuolated fibers which were features of colchicine-induced myopathy. The clinical improvement
and decreasing in muscle enzyme level occurred after colchicine withdrawal. Other potential
causes of myopathy such as chronic renal failure and other drugs were ruled out. We suggested
that colchicine should be used with caution in the presence of renal failure especially when other
drugs which affect the metabolism of colchicine are also prescribed.
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