J Med Assoc Thai 1997; 80 (11):731

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Pattern of Bone Loss in Surgical Menopause : A Preliminary Report
Chittacharoen A Mail, Theppisai U , Sirisriro R , Thanantaseth C

The objective of our study was to assess bone mineral density between surgical menopausal
women without hormonal replacement and perimenopausal women. This randomized study
group included fifty surgical menopausal women and fifty perimenopausal women. Both groups
were assessed in body height, body weight and body mass index. The bone mineral density of the
distal radius, midradius, femoral neck, lumbar spine and total body in both groups was determined
by dual energy X-ray absorptiometry (DEXA). Data analysis was used ANOV A test and rate of bone
loss equation. Both groups were similar with respect to body height, body weight and body mass
index. As compared with the values in perimenopausal group, bone mineral density of the surgical
menopausal group was significantly lower at distal radius, midradius, femoral neck, lumbar
spine, and total body (0.267 vs 0.312 g!cm2, 0.609 vs 0.692 g/cm2, 0.762 vs 0.930 g/cm2, 0.980 vs
1.153 g/cm2, and 1.029 vs 1.141 g/cm2). In the postmenopausal period less than 9 years, the
estimated rate of bone loss at the lumbar spine and the distal radius were higher than the other sites
(3.05, 2.70 per cent/year). While the postmenopausal period more than 9 years, the estimated rate
of bone loss at the femoral neck was higher than the other sites (2.70 per cent/year). Pattern of bone
loss in the surgical menopause is responsible for type I osteoporosis in the first 9 years postmenopause
and type II osteoporosis in the after 9 years postmenopause. Prevention of bone loss
in the surgical menopausal women should be instituted immediately after surgery.

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